ICI 90-Day Severe irAE Risk
Predicts probability of ≥G3 immune-related adverse events.
Age
(years)
ECOG Performance Status
0 - Fully active
1 - Restricted strenuous activity
2 - Ambulatory, self-care
3 - Limited self-care
4 - Bedbound
Cancer Type
Urothelial (Reference)
Melanoma
NSCLC
RCC
HCC
Other/Unknown
ICI Regimen
PD-1 / PD-L1 (Reference)
CTLA-4
Combination (PD-1 + CTLA-4)
Pre-existing Autoimmune Disease?
Albumin
(g/L)
CRP
(mg/L)
LDH
(U/L)
Neutrophils
(×10⁹/L)
Lymphocytes
(×10⁹/L)
Calculate Risk
Low Risk
4.5%